New research reveals shifting identities of global fishing fleet to help bolster fisheries management

Scientific study fuses multiple data sources to advance global understanding of vessel identity and behavior

WASHINGTON, D.C., Jan. 18, 2023 (GLOBE NEWSWIRE) — A new study published today in Science Advances combines a decade’s worth of satellite vessel tracking data with identification information from more than 40 public registries to determine where and when vessels responsible for most of the world’s industrial fishing change their country of registration, a practice known as “reflagging”, and identify hotspots of potential unauthorized fishing and activity of foreign-owned vessels.

Using big data processing and a compilation of global datasets, researchers from Global Fishing Watch, the Marine Geospatial Ecology Lab from Duke University, and Stockholm Resilience Centre were able to track and analyze 35,000 commercial fishing and support vessels to reveal their changing identities and enable the reconstruction of vessel histories to demonstrate reflagging patterns.

The study, “Tracking Elusive and Shifting Identities of the Global Fishing Fleet” found that close to 20 percent of high seas fishing is carried out by vessels that are either internationally unregulated or not publicly authorized, with large concentrations of these ships operating in the Southwest Atlantic Ocean and the western Indian Ocean.

The data used in the study is intended to complement the Food and Agriculture Organization of the United Nations’ Global Record of Fishing Vessels, Refrigerated Transport Vessels and Supply Vessels, a flagship transparency initiative which serves as the official database of information on vessels used for fishing and fishing-related activities. Together with the International Maritime Organization’s ship identification number scheme, these resources can provide fisheries authorities with the information needed to adequately monitor vessel activity, implement flag State responsibilities, and inform responsible fisheries management.

“Until now, we’ve had limited information linking together the identity and activity of specific vessels,” said Jaeyoon Park, senior data scientist at Global Fishing Watch and lead author of the study. “When a vessel’s identity is changed, it makes tracking them all the more difficult, allowing bad actors the opportunity to take advantage of information gaps and avoid oversight. We need to close that loophole.”

Of the 116 States involved in reflagging, the study found that one-fifth of them were responsible for about 80 percent of this practice over the past decade, with most reflagging occurring in Asia, Latin America, Africa, and the Pacific Islands. The study found that reflagging takes place in just a few ports—Las Palmas de Gran Canaria, Busan, Zhoushan, and Kaohsiung have the highest activity. Vessels are often reflagged to States that are unrelated to the ports in which they are changing their registrations. This means that a vessel can change its flag from one country to another without ever having to enter port in either of those countries.

While there are legitimate reasons for a vessel to change its identity, abusive reflagging, or “flag hopping,” is one way that operators avoid oversight. The study found that fleets with prevalent reflagging are over five times more likely to be composed of vessels under foreign ownership which are often registered to “flags of convenience,” defined by the International Transport Workers’ Federation as countries that offer foreign shipowners the ability to register, or fly the flag, of their own State.

While reflagging and foreign ownership are lawful, when not properly regulated and monitored, they can indicate a risk of illegal, unreported and unregulated (IUU) fishing. IUU fishing accounts for as much as 20 percent of the global seafood catch with annual losses valued at up to $23.5 billion.

“Knowing the identities of vessels fishing the high seas is critical for uncovering the connection between the potential IUU fishing behavior and vessels that repeatedly change their name, flag State or registered owner,” said co-author Gabrielle Carmine, a doctoral candidate at Duke University’s Nicholas School of the Environment. “This analysis could be used to help monitor fisheries more effectively and for accountability in the use and protection of marine biodiversity.”

The study also identified concentrations of fishing activity by foreign-owned vessels, which are focused in parts of the high seas and certain national waters, including the southwest Pacific, the northwest Indian Ocean, Argentina and the Falkland Islands (Malvinas), and West Africa where vessels are typically owned by China, Chinese Taipei, and Spain. The hotspots in this study correspond to the areas in which multiple nongovernmental organizations have called for better governance systems.

“By synthesizing more than 100 billion GPS positions with consolidated identity information from 200,000 vessels, we were able to reveal patterns about vessel activity from the past decade,” added Park. “This study represents a major step forward in our ability to enhance monitoring efforts and help authorities direct enforcement resources.”

The data used in this study will be periodically updated and shared publicly to help enable better understanding of vessel behavior and bolster international fisheries management.

Notes to the editor:

  • Download data visualizations, video, and figures from the paper here: https://drive.google.com/drive/folders/11T-UNkRQmlktINuTw5ufurNFuzAIxTu8?usp=share_link
  • Data visualization caption: Data analysis in this study’s assessment of fishing compliance revealed hotspots of fishing activity by foreign-owned vessels in the southwest Pacific, the west Indian oceans, and certain national waters.
  • About vessel identity data: The data used to determine vessel identities in this study were based on public registries. A lack of vessel identity information exists at the national level, while the high seas are predominantly covered by registries published by regional fisheries management organizations. The identity data used in this study has more extensive coverage for vessels that are 24 meters and longer, as these vessels are more likely to be registered to national or international public registries than smaller ones.
  • About AIS data: First developed as a collision-avoidance system, AIS is essential to vessel and crew safety. But AIS is easily manipulated, as it can simply be switched off or allow the transmission of false information, such as a vessel’s name, type or location. Currently there is no global mandate for all fishing vessels to broadcast on AIS. And due to the varying quality of satellite reception by region, there is also unequal coverage of AIS data throughout the world. Most vessels larger than 24 meters are equipped with AIS while only a small fraction of vessels smaller than 24 meters use AIS, resulting in limitations in AIS data.
  • Paper citation: J. Park, J. Van Osdel, J. Turner, C. M. Farthing, N. A. Miller, H. L. Linder, G. Ortuño Crespo, G. Carmine, D. A. Kroodsma, Tracking elusive and shifting identities of the global fishing fleet. Sci. Adv. 9, eabp8200 (2023).
  • Download the data at: https://globalfishingwatch.org/data-download/datasets/public-vessel-identity:v20230118 

Global Fishing Watch is an international nonprofit organization dedicated to advancing ocean governance through increased transparency of human activity at sea. By creating and publicly sharing map visualizations, data and analysis tools, we aim to enable scientific research and transform the way our ocean is managed. We believe human activity at sea should be public knowledge in order to safeguard the global ocean for the common good of all.

Attachment

Lisa Tossey
Global Fishing Watch
+1-302-448-6638
lisa.tossey@globalfishingwatch.org

GlobeNewswire Distribution ID 8732331

Disposable Vaping Devices Wreak Havoc On Our Global Ecosystem

Pure Labs Urges Government Entities to Put an End to This Major Source of Environmental Pollution & Youth Vaping

Disposable Vape Waste

Heavy metals, toxic chemicals, and residual nicotine from littered disposable vape devices leach into our soil and pollute our ecosystem and wildlife.

TAMPA, Fla., Jan. 17, 2023 (GLOBE NEWSWIRE) — Not only are disposable vaping devices fueling the world’s ongoing youth vaping epidemic, these single-use plastic e-cigarettes are responsible for the growing, exorbitant amount of toxic waste plaguing our earth. As if it isn’t harmful enough that disposable vape products are purposely targeting our youth with brightly colored packaging, eye-catching branding, and appealing fruit & dessert flavors; the plastics, heavy metals, and lithium batteries that these devices are comprised of are now a leading source of environmental pollution.

Similar to what we’ve seen with combustible cigarette butts, littered disposable vaping devices are now a major source of contamination to our ecosystem, on a worldwide scale. The issue is not just the non-decomposable plastic casings we see scattered in the streets, on beaches, and in parks far too often. Disposable vaping devices also leach hazardous waste from their lithium batteries and heavy metals from their circuitry systems. The moment these toxic materials penetrate our environment, the corruption of our ecosystem and our wildlife begins. In addition to the harmful and toxic chemicals found in lithium batteries, these types of batteries are known to explode or start fires if disposed of improperly. Not to mention the illegal child labor associated with up to 30% of cobalt mining facilities responsible for sourcing the material used in lithium-ion batteries.

With disposable devices being the preferred method of vaping among our youth, it is no mystery why we are seeing as much e-cigarette pollution as we are today. A standard disposable vape pen only holds enough E-liquid to last a few days, causing the average user to cycle through approximately 2 to 3 devices per week. That’s a lot of waste! Every day, respective Customs entities are seeing thousands of palettes of these disposable vape devices enter from China. If we want to take action and do our part to mitigate the global environmental pollution crisis and the undeniable youth vaping epidemic, we need to stop the infection at its root – put an end to Chinese disposable vaping devices.

About Pure Laboratories

Operating since 2009, Pure Laboratories (Pure Labs) is a Veteran-Owned state-of-the-art 110,000-sq. ft. manufacturing and distribution facility located in Gainesville, Florida. Nicopure Labs, a subsidiary of Pure Labs, is an industry leading manufacturer of American-Made tobacco and menthol E-liquid products. Nicopure Labs is best known for its award-winning E-liquid and hardware brand, Halo. With a 10,000-sq. ft. cleanroom, Pure Labs is synonymous with quality manufacturing. Pure Labs’ corporate headquarters are based in Tampa Florida, with additional operations located in Europe.

For additional information about carrying Halo’s premium American-made e-liquid and innovative line of vaporizer devices, please email Halo’s principal distribution partner, Syndicate Distribution at sales@syndicatedistribution.com.

For additional information on Pure Laboratories’ full capabilities visit www.PureLabs.com.

For media inquiries, please email [email protected]

Contact:
Samantha Knight
Pure Labs
[email protected]

GlobeNewswire Distribution ID 8729729

Crurated Raises $7.2 MM to Further Innovate Blockchain-Based Wine Community and Expand Market Reach

After another successful year the company will also begin to partner with wine producers beyond France and Italy

Crurated Connects Connoisseurs with World-Class Producers

Crurated Raises $7.2 MM to Further Innovate Blockchain-Based Wine Community and Expand Market ReachAfter another successful year the company will also begin to partner with wine producers beyond France and Italy

LONDON, Jan. 17, 2023 (GLOBE NEWSWIRE) —  Crurated, the London-based membership wine community designed to connect connoisseurs with world-class producers, today announced that the company has raised $7.2 MM from a group of private investors. The money will be used to further evolve the technology platform, expand producer partnerships beyond France and Italy, and increase overall market share across the globe.

“The past year has been both innovative and successful for our entire team and the producers we’ve partnered with,” said Alfonso de Gaetano, founder of Crurated. “In addition to becoming the first wine community to offer fractional barrel sales backed by NFT technology, we signed an exclusive distribution deal with Charles Lachaux, grew our roster of producers to more than 60, and have attracted a younger demographic of oenophiles onto the platform.”

Crurated Wine Bottles With NFC RFID

Crurated is the first wine community to offer fractional barrel sales backed by NFT technology

Crurated reports that 70% of its member base is below the age of 45. With 35% of those members under the age of 35, younger than the majority of wine buyers which skews at 45+. The team believes that Crurated’s direct partnerships with the world’s top wine producers, innovative approach to how wine is purchased on the platform — traditional lot purchases/auctions and fractional barrel sales — as well as the use of NFTs to validate a wine’s authenticity is helping to increase the interest in wine with a younger demographic.

In addition, revenues were up 214% in the first half of year two vs. the first half of year one. Membership grew by 180% in the first half of year 2 vs. the first half of year 1 and is up 400% year to date.

About Crurated
Launched in 2021 with an emphasis on France and Italy, Crurated is a membership-based wine community designed to connect connoisseurs with world-class producers. A team of specialists provides personalized services and authentic experiences, while Crurated’s seamless logistics service guarantees quality and provenance thanks to secure wine cellar storage and innovative blockchain technology. For more on Crurated, visit crurated.com.

PR Contact
Michael Volpatt
[email protected]
415.994.8864

A video accompanying this announcement is available at

https://www.globenewswire.com/NewsRoom/AttachmentNg/1d1a5202-186e-4b6a-8783-aa82bbb8e388

Photos accompanying this announcement are available at

https://www.globenewswire.com/NewsRoom/AttachmentNg/0988a38c-6f44-4feb-ac1d-c734d7ccc165

https://www.globenewswire.com/NewsRoom/AttachmentNg/e7ba4d88-1de4-4f87-b6ee-d6026b3298c2

GlobeNewswire Distribution ID 8730478

Elo Partners with FreedomPay to Transform the Digital In-Store Experience

PHILADELPHIA, Jan. 16, 2023 (GLOBE NEWSWIRE) — FreedomPay, the global leader in Next Level Commerce™, and Elo, a leading global provider of interactive solutions and interactive display solutions, announce the integration of Elo’s M60 Pay handheld computer with FreedomPay’s secure commerce technology.

Built to accept today’s popular payment and loyalty cards, the M60 Pay has a built-in EMV, magnetic stripe reader and NFC for cards with either chips or strips and digital contactless payments. The Android®-based M60 Pay computer can transform from a mobile to a fixed POS solution with the optional docking station, expansion module and Elo touchscreen monitor.

Together, FreedomPay and Elo are reinventing the digital in-store experience by uniting Elo’s innovative and interactive solutions with FreedomPay’s industry-leading commerce technology platform to create a secure, frictionless, unified shopping experience for global consumers while supporting merchants with robust loyalty and data analytics capabilities.

“The M60 Pay makes decentralizing the checkout process and taking payments anywhere easy,” said Craig Witsoe, CEO at Elo. “The partnership with FreedomPay will bring enhanced functionality and security to create a more personalized experience for consumers.”

FreedomPay’s Next Level Commerce™ platform offers many benefits to merchants and their customers, including:

  • The ability to unify commerce across properties, channels, and regions within a single open, fully agnostic, flexible platform;
  • A touchless ecosystem that supports contactless payments, QR technology, Apple Pay, and Google Pay; and
  • A fully integrated end-to-end solution enabling secure payments, identity-as-a-service, loyalty, and business intelligence.

“Consumers are looking continually for new payment functionality and greater customization when it comes to payments. The partnership with Elo will give customers secure and seamless checkout experience expected with FreedomPay coupled with the innovative and modular designed solutions from Elo,” said Tom Durovsik, Founder & CEO of FreedomPay.

To learn more about the solution, visit FreedomPay at NRF booth #4250 or Elo at NRF booth #5803 to request a demo.

About FreedomPay
FreedomPay’s Next Level Commerce™ platform transforms existing payment systems and processes from legacy to leading edge. As the premier choice for many of the largest companies across the globe in retail, hospitality, lodging, gaming, sports and entertainment, foodservice, education, healthcare and financial services, FreedomPay’s technology has been purposely built to deliver rock-solid performance in the highly complex environment of global commerce. The company maintains a world-class security environment and was first to earn the coveted validation by the PCI Security Standards Council against Point-to-Point Encryption (P2PE/EMV) standard in North America. FreedomPay’s robust solutions across payments, security, identity, and data analytics are available in-store, online and on-mobile and are supported by rapid API adoption. The award-winning FreedomPay Commerce Platform operates on a single, unified technology stack across multiple continents allowing enterprises to deliver an innovative Next Level experience on a global scale. www.freedompay.com

About Elo
As a leading global supplier of interactive solutions, #EloIsEverywhere. To date, Elo has deployed more than 25 million installations in over 80 countries. A new Elo touchscreen is installed every 21 seconds, on average, somewhere in the world. Built on a unified architecture, Elo’s broad portfolio allows its customers to easily Choose, Configure and Connect & Control to create a unique experience. Choose from all-in-one systems, open-frame monitors and touchscreen monitors ranging from 7 to 65 inches. Configure with Elo’s unique Elo Edge Connect® peripherals that allow use-specific solutions. Connect & Control with EloView®, a secure, cloud-based platform for Android-powered devices. EloView enables secure deployment and management of a large network of interactive systems designed to reduce operating costs while increasing up-time and security.

Consumers can find Elo touchscreen solutions in self-service kiosks, point-of-sale terminals, interactive signage, gaming machines, hospitality systems, point-of-care displays and transportation applications, to name a few. Learn more at EloTouch.com.

Contact

Jennifer Tayebi
Hill+Knowlton Strategies for FreedomPay
Jennifer.Tayebi@hkstrategies.com
+1 734 395 0780

GlobeNewswire Distribution ID 8730050

FreedomPay to Unleash the Power of Pay at NRF 2023

One of the world’s fastest growing fintech to showcase award-winning global commerce technology platform and industry-leading partner network.

NEW YORK, National Retail Federation, Jan. 15, 2023 (GLOBE NEWSWIRE) — FreedomPay, the global leader in Next Level Commerce™ and the commerce technology platform of choice for global retail, hospitality and payments brands including Marriott, Foot Locker, Shake Shack, Engage People, and Castles Technology, will showcase its innovations and partnership announcements this week at NRF in booth #4250.

The event will mark the launch of FreedomPay’s new call to action, Unleash the Power of Pay. As the commerce landscape evolves with new technologies and changing consumer needs, Unleash the Power of Pay introduces the notion of unleashing the power of payments to drive greater customer loyalty, leverage business intelligence insights, and bring value-added services.

“FreedomPay is excited to make a splash at this year’s NRF and to launch Unleash the Power of Pay. The concept is a testament to our award-winning technology and best-in-class partner network that is enabling billions of transactions in more than 75 countries across the globe,” said Tom Durovsik, Founder & CEO of FreedomPay.

As part of its line-up at NRF, FreedomPay will host a roundtable discussion on Monday, January 16 at 10:30AM at booth #4250 with industry influencers Castles Technology, Charter Communications, and Elo Touch, moderated by Dale Laszig of the Green Sheet. The event, Next Level Commerce™: Unleashing the Power of Pay, will focus on the challenges and opportunities across retail, the trends influencing retail’s future, and strategies for merchants to navigate the changing retail sector. Those who would like to attend virtually are encouraged to register here.

FreedomPay also announces the publication of a new industry white paper The Next Level of Global Payments: Unleash the Power of Pay. The report highlights pivotal opportunities for retailers to elevate customer relationships and increase profit margins internationally, outlining strategies for security, safety, speed, simplicity, and customer satisfaction with service across borders. Download now to read the bespoke report.

FreedomPay’s global footprint continues to grow through the power of its partner network and new integrations to allow merchants to Unleash the Power of Pay for their customers. FreedomPay also announced in the days leading up to NRF 2023 new partnerships that will bring its solutions to more merchants around the world.

Moneris Solutions Corporation (“Moneris”), the largest payment processor in Canada*, will now be able to offer its merchants access to FreedomPay’s commerce technology platform, bringing an enhanced checkout experience to millions of shoppers across Canada.

FreedomPay also announced an integration with Flooid, bringing enhanced innovation, choice, and flexibility to retailers around the globe on the Flooid platform.

To learn more about FreedomPay, visit us at NRF booth #4250 or www.freedompay.com.

About FreedomPay

FreedomPay’s Next Level Commerce™ platform transforms existing payment systems and processes from legacy to leading edge. As the premier choice for many of the largest companies across the globe in retail, hospitality, lodging, gaming, sports and entertainment, foodservice, education, healthcare and financial services, FreedomPay’s technology has been purposely built to deliver rock solid performance in the highly complex environment of global commerce. The company maintains a world-class security environment and was first to earn the coveted validation by the PCI Security Standards Council against Point-to-Point Encryption (P2PE/EMV) standard in North America. FreedomPay’s robust solutions across payments, security, identity, and data analytics are available in-store, online and on-mobile and are supported by rapid API adoption. The award winning FreedomPay Commerce Platform operates on a single, unified technology stack across multiple continents allowing enterprises to deliver an innovative Next Level experience on a global scale. www.freedompay.com

*Based on total number of transactions processed in Canada

Jennifer Tayebi
Hill+Knowlton Strategies for FreedomPay
+1 734 395 0780
Jennifer.Tayebi@hkstrategies.com

GlobeNewswire Distribution ID 8729731

Flooid Announces Strategic Partnership with FreedomPay to Expand Global Reach

The partnership will bring enhanced commerce functionality to Retailers around the world.

London, England, Jan. 13, 2023 (GLOBE NEWSWIRE) — Flooid today announces a strategic partnership with FreedomPay, the global leader in Next Level Commerce™, to bring industry-leading Retail solutions to merchants globally.

Powered by FreedomPay, Flooid allows merchants to connect their retail channels, removing barriers between online and in-store payments. FreedomPay’s data-driven commerce platform grants merchants access to valuable analytics and Business Intelligence platform to drive further customer engagement and loyalty through targeted offers and incentives, all within a frictionless integrated payment solution.

“Through this partnership with FreedomPay, we are bringing enhanced innovation, choice, and flexibility to retailers on the Flooid platform,” said Donna Stevens, Senior VP of Product and Marketing at Flooid. Our goal is to empower merchants with the tools they need to provide the best shopping experience to consumers globally.”

The FreedomPay platform enables enterprises to provide a consistent payment experience for their customers globally, creating a seamless and flexible retail experience managing security, data and loyalty all from a single, unified tech stack.

“The partnership between FreedomPay and Flooid will bring a world-class commerce experience to retailers and shoppers around the globe,” said Liesl Smith, Senior VP of Marketing and Sales Enablement at FreedomPay. “Together we are committed to delivering a seamless payment experience to customers, enabling an innovative and seamless omnichannel payment environment.”

About FreedomPay

FreedomPay’s Next Level Commerce™ platform transforms existing payment systems and processes from legacy to leading edge. As the premier choice for many of the largest companies across the globe in retail, hospitality, lodging, gaming, sports and entertainment, foodservice, education, healthcare and financial services, FreedomPay’s technology has been purposely built to deliver rock solid performance in the highly complex environment of global commerce. The company maintains a world-class security environment and was first to earn the coveted validation by the PCI Security Standards Council against Point-to-Point Encryption (P2PE/EMV) standard in North America. FreedomPay’s robust solutions across payments, security, identity, and data analytics are available in-store, online and on-mobile and are supported by rapid API adoption. The award winning FreedomPay Commerce Platform operates on a single, unified technology stack across multiple continents allowing enterprises to deliver an innovative Next Level experience on a global scale. www.freedompay.com

About Flooid

Flooid helps retailers create the seamless shopping experiences customers demand. Flooid’s unified commerce platform empowers merchants to sell to customers flexibly and consistently wherever they are and however they choose to shop. Our best of breed open ecosystem givers retailers the power to connect leading retail tech partners with a single unified commerce platform to engage with your shoppers, sell more effectively across channels and adapt to retail shopping changes we have yet to imagine.

Jennifer Tayebi
Hill+Knowlton Strategies for FreedomPay
+1 734 395 0780
Jennifer.Tayebi@hkstrategies.com

GlobeNewswire Distribution ID 8729158

Sabin Vaccine Institute Receives $35 Million from BARDA with Potential of up to $214 Million for Ebola Sudan and Marburg Vaccines

Sabin Vaccine Institute Awarded BARDA Contract With Funding Potential up to $214M for Ebola Sudan and Marburg Vaccines

The Sabin Vaccine Institute will produce up to 100,000 doses of Sabin’s Ebola Sudan vaccine as part of a new, multi-year contract with BARDA

WASHINGTON, Jan. 12, 2023 (GLOBE NEWSWIRE) — The Sabin Vaccine Institute today announced that the Biomedical Advanced Research and Development Authority (BARDA) has awarded Sabin a multi-year contract with funding potential for up to $214 million to advance the development and production of single-dose vaccine candidates for Ebola Sudan and Marburg virus diseases.

There are currently no licensed vaccines against Ebola Sudan and Marburg viruses, which cause hemorrhagic fever and kill approximately half the people infected.

BARDA, part of the U.S. Department of Health and Human Services’ Administration for Strategic Preparedness and Response (ASPR), will initially invest approximately $35 million to produce up to 100,000 doses of Sabin’s Ebola Sudan virus (ChAd3-SUDV) vaccine. These vaccines may be used as part of ongoing U.S. preparedness efforts and in response to future global outbreaks.

The Sabin vaccine was the first to arrive in Uganda during the recent Ebola Sudan virus outbreak that caused 55 deaths after the World Health Organization included it as one of three vaccines for possible use in an outbreak trial in Uganda. The country declared the Ebola Sudan outbreak had ended on January 11, four months after the first confirmed case.

“Sabin successfully delivered Ebola Sudan vaccine doses to Uganda within 79 days of the start of the outbreak – quite an impressive accomplishment,” says Sabin Chief Executive Officer Amy Finan. “This new contract enables Sabin to produce up to 100,000 doses so the world is prepared in advance for future outbreaks.”

In addition to participating in recent outbreak activities, Sabin continues its Sudan development plan and has initiated Phase 2 clinical trial planning in Uganda and Kenya. Based on previous clinical trials, Sabin’s Ebola Sudan vaccine is safe and immunogenic, and in nonhuman primate studies has demonstrated rapid protection, durability up to 12 months, and efficacy.

In addition to Sabin’s ChAd3-SUDV vaccine, the contract also includes support to manufacture Sabin’s vaccine against Marburg virus (ChAd3-MARV), which would generate doses that could also be used in trials and in response to a possible Marburg virus outbreak. As recently as last July, two people in Ghana died after being infected with Marburg virus, reinforcing the urgent need for a vaccine.

The new contract leverages a partnership with BARDA that began in 2019, when the agency awarded Sabin another multi-year contract valued at $128 million to further the development of vaccines against both the Marburg and Ebola Sudan viruses.

“BARDA has been a supportive partner as we take these essential steps in pandemic preparedness,” said Finan. “The Ebola Sudan outbreak in Uganda underscored the critical need for readily available solutions. We’ll now have ample material to respond quickly to such an outbreak in the future.”

This project will be funded in whole with federal funds from the Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority, under contract number 75A50123C00010.

About the Sabin Vaccine Institute

The Sabin Vaccine Institute is a leading advocate for expanding vaccine access and uptake globally, advancing vaccine research and development, and amplifying vaccine knowledge and innovation. Unlocking the potential of vaccines through partnership, Sabin has built a robust ecosystem of funders, innovators, implementers, practitioners, policy makers and public stakeholders to advance its vision of a future free from preventable diseases. As a non-profit with three decades of experience, Sabin is committed to finding solutions that last and extending the full benefits of vaccines to all people, regardless of who they are or where they live. At Sabin, we believe in the power of vaccines to change the world. For more information, visit www.sabin.org and follow us on Twitter, @SabinVaccine.

About Ebola Sudan and Marburg

Ebola Sudan and Marburg are members of the filovirus family. Both can cause severe hemorrhagic fever in humans and nonhuman primates. No therapeutic treatment of these hemorrhagic fevers has been licensed to date. Marburg and Ebola viruses are transmitted to humans by infected animals, particularly fruit bats. Once a human is infected, the virus can spread to others through close personal contact or contact with bodily fluids. Isolation of infected people is currently the centerpiece of filovirus control.

Marburg was the first filovirus to be recognized in 1967 when outbreaks of hemorrhagic fever were reported in a few Europe-based laboratories including in the town of Marburg, Germany. Ebola was identified in 1976 when two simultaneous outbreaks occurred in northern Zaire (now the DRC) in a village near the Ebola River and in southern Sudan. The outbreaks involved what eventually proved to be two different species of Ebola virus; both were named after the nations in which they were discovered.

For media inquiries:

[email protected]

Media Contact:
Monika Guttman
Media Relations Specialist
Sabin Vaccine Institute
+1 (202) 662-1841
[email protected]

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/539c9127-e5d6-4b32-9e89-780f7461314b

GlobeNewswire Distribution ID 8728283

Zenas BioPharma Announces First Patient Dosed in Phase 3 Clinical Study of Obexelimab for the Treatment of Immunoglobulin G4-Related Disease (IgG4-RD)

Global Phase 3 INDIGO study will evaluate the efficacy and safety of obexelimab in patients with IgG4-RD, a chronic and serious fibroinflammatory disease typically affecting multiple organs

IgG4-RD is the first of several potential disease indications to be pursued for obexelimab given its unique non-depleting, B-cell inhibition

WALTHAM, Mass., Jan. 11, 2023 (GLOBE NEWSWIRE) — Zenas BioPharma, a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune-based therapies, today announced that the first patient has been dosed in the INDIGO Phase 3 registrational study of obexelimab. The INDIGO study will evaluate the clinical efficacy and safety of obexelimab treatment in the prevention of IgG4-related disease (IgG4-RD) flare. Obexelimab is a high-affinity bifunctional antibody that inhibits B-cell lineages by simultaneously binding to CD19 and FcƳRIIB, thereby downregulating B-cell activity in patients with autoimmune diseases associated with autoantibodies, such as IgG4-RD.

“IgG4-RD is a chronic and serious fibroinflammatory condition that can affect nearly any organ system and can have a profound impact on many patients, leading to severe organ damage or death,” said Hua Mu, M.D., Ph.D., Chief Executive Officer at Zenas. “There are no currently approved treatments for patients living with IgG4-RD. Based upon the promising data from a Phase 2 study of obexelimab in IgG4-RD patients, we are excited to continue to evaluate the potential of obexelimab in the INDIGO study.”

About the INDIGO Study

The INDIGO study is a global multicenter, randomized, double-blind, placebo-controlled study enrolling up to 200 adults with active IgG4-RD signs/symptoms (i.e., flare) that require steroid therapy. Patients will be randomized in a ratio of 1:1 to receive either obexelimab or placebo, administered as subcutaneous injections.

The primary endpoint of INDIGO is time to first IgG4-RD flare (defined as the reappearance of previous signs/symptoms or appearance of new signs/symptoms of IgG4-RD) that requires initiation of rescue therapy from randomization to Week 52. Safety will be evaluated throughout the study duration.

More information on the INDIGO study (NCT05662241) is available at clinicaltrials.gov.

About Obexelimab

Obexelimab is an investigational Phase 3-stage, novel bifunctional antibody with first-in-class potential that inhibits B-cell lineages that express CD19. Simultaneous binding to CD19 and FcƳRIIB by obexelimab mimics a natural antigen-antibody complex and downregulates B cell activity. In several early-stage clinical studies, 198 subjects were treated with obexelimab. In these clinical studies, the molecule demonstrated effective inhibition of B cell function without depleting the cells and generated an encouraging treatment effect in patients with multiple autoimmune diseases. Zenas acquired exclusive worldwide rights to obexelimab from Xencor, Inc.

About IgG4-RD

IgG4-RD is a chronic and serious fibroinflammatory disease typically affecting multiple organs (e.g., pancreas, liver, kidney, bile duct, salivary and lacrimal glands). Approximately 20,000 people are diagnosed with IgG4-RD in the US, with similar prevalence rates across geographies. Many patients have some degree of irreversible organ damage at the time of diagnosis. Although nearly all patients initially respond to glucocorticoid (GC) therapy, a majority of patients will relapse/flare within a few months of discontinuing treatment, requiring rescue therapy. Chronic GC therapy is also associated with toxicity in many patients.

About Zenas BioPharma

Zenas BioPharma is a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune-based therapies for patients around the world. With clinical development and operations globally, Zenas is advancing a deep and balanced global portfolio of potential first- and best-in-class autoimmune therapeutics in areas of high unmet medical need while meeting the value requirements of the dynamic global healthcare environment. The company’s pipeline continues to grow through our successful business development strategy. Our experienced leadership team and network of business partners drive operational excellence to deliver potentially transformative therapies to improve the lives of those living with autoimmune and rare diseases. For more information about Zenas BioPharma, please visit www.zenasbio.com and follow us on Twitter at @ZenasBioPharma and LinkedIn.

Investor and Media Contact:
Joe Farmer, President & COO
Zenas BioPharma
[email protected]

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